Severe aplastic anaemia.

Severe aplastic anaemia--an aetiological correlation.

Over 4 years, 43 cases of severe aplastic anaemia (SAA) were seen. Etiologically 58.1% had idiopathic, 39.5% secondary and 2.3% congenital aplastic, anaemia. Idiopathic SAA was more common in patients between 0-15 years of age, whereas secondary SAA was more frequent in 16-60 years age group. Males were more commonly affected with a male:female ratio of 3.3:1. Amongst 17 cases of secondary SAA,...

Aplastic Anaemia.

Aplastic anaemia: a review.

Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppress...

Aplastic Anaemia in Children.

A anaemia is a life threatening blood disorder that affects a large number of children each year in India. Exposure to toxic agents like benzene, radiation and viruses like hepatitis A have been implicated in its aetiology. The incidence in developing countries is far higher compared to developed countries. Investigating a child with pancytopenia is more complex than that of an adult as numerou...

Successful pregnancy following aplastic anaemia.

Pregnancy following idiopathic aplastic anaemia is rare and is difficult to manage because of life-threatening episodes of bleeding and infections. Only a handful of cases has been reported in the literature. The pregnancies were unsuccessful in the majority. The present report describes a patient with moderately severe idiopathic aplastic anaemia who was managed with intensive haematological s...